Maximum Tolerated Dose - Bioanalytical Research

Relevant Publications

Review of dose setting for the Extended One-Generation Reproductive Toxicity Studies (OECD TG 443): considerations on ECHA\'s dose level selection recommendations.

Issue Release: 2024

Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study.

Issue Release: 2024

A phase I study of TAK-659 and paclitaxel in patients with taxane-refractory advanced solid tumors.

Issue Release: 2024

The safety and efficacy outcomes of Minnelide given alone or in combination with paclitaxel in advanced gastric cancer: a Phase I trial.

Issue Release: 2024

A phase I safety and efficacy clinical trial of plocabulin and gemcitabine in patients with advanced solid tumors.

Issue Release: 2024

Phase 1 study of NEDD8 activating enzyme inhibitor pevonedistat in combination with chemotherapy in pediatric patients with recurrent or refractory solid tumors (ADVL1615).

Issue Release: 2024

Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitization.

Issue Release: 2024

Combination Therapy of Lenvatinib and Hepatic Arterial Infusion Chemotherapy Using Cisplatin With Lipiodol and 5-Fluorouracil: A Potential Breakthrough Therapy for Unresectable Advanced Hepatocellular Carcinoma.

Issue Release: 2024

Stereotactic central/core ablative radiation therapy: results of a phase I study of a novel strategy to treat bulky tumor.

Issue Release: 2024

Design and baseline characteristics of the Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) randomized trial.

Issue Release: 2024

A Phase 1a Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7303509, an Anti-TGFβ3 Antibody, in Healthy Volunteers.

Issue Release: 2024

Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway.

Issue Release: 2024

ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study.

Issue Release: 2024

BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: a first-in-human, open-label, multicentre, phase 1 study.

Issue Release: 2024

Pharmacokinetics and Bioequivalence of Two Formulations of Azithromycin Tablets: A Randomized, Single-Dose, Three-Period, Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions.

Issue Release: 2024

Phase I trial of dose escalation for preoperative stereotactic radiosurgery for patients with large brain metastases.

Issue Release: 2024

Dual Drug Repurposing: The Example of Saracatinib.

Issue Release: 2024

Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial.

Issue Release: 2024

Randomized Trial of Pharmacokinetic and Pharmacodynamic Effects of 13.2 mg Intranasal Epinephrine Treatment in Congestion.

Issue Release: 2024

Phase 1 study of azacitidine in combination with quizartinib in patients with FLT3 or CBL mutated MDS and MDS/MPN.

Issue Release: 2024

Why is Accuracy Important?

Why is Precision Important?

How is Standardization Achieved?

What are the Applications of Amplification in Bioanalytical Sciences?

What are the Challenges in Ensuring Reliability?

What are Validation Parameters?

How is Genomic Sequencing Performed?

How Do These Advancements Benefit the Field?

How Does Bioanalytical Research Contribute to Drug Development?

How Does NMR Spectroscopy Aid in Structural Analysis?

Maximum Tolerated Dose - Bioanalytical Research

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