What Are the Challenges Associated with Pressure Driven Flow?

Despite its advantages, pressure driven flow also presents some challenges, such as:
- Pressure Control: Maintaining a stable and precise pressure gradient can be challenging, especially in microscale systems.
- Channel Clogging: Small channels in microfluidic devices are prone to clogging, which can disrupt the flow and compromise analyses.
- Sample Loss: High pressure gradients can lead to sample loss or degradation, particularly for delicate biological samples.

Addressing these challenges requires careful system design and optimization.