What Challenges are Associated with Chromatography in Bioanalytical Sciences?
While chromatography is highly effective, it faces challenges such as:
1. Matrix Effects: Biological samples often contain interfering substances that can affect the accuracy of the analysis.
2. Complex Sample Preparation: Preparing biological samples for chromatography can be time-consuming and requires meticulous attention to detail.
3. Sensitivity and Specificity: Although highly sensitive, chromatography methods must be carefully optimized to distinguish between closely related compounds.
