Selectivity is typically assessed by comparing the analytical response obtained from the test sample with that of a blank sample (a sample that contains all matrix components except the analyte). Methods such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) are often employed to ensure high selectivity. Analysts also use spiking experiments, where known quantities of the analyte are added to the sample to observe the methodâs ability to accurately recover the analyte.
