Despite their importance, there are several challenges associated with using QC samples:
Matrix Effects: The biological matrix can affect the accuracy and precision of the analytical method, making it crucial to use matrix-matched QC samples. Stability Issues: Analytes in QC samples may degrade over time, leading to erroneous results if not properly stored and handled. Variability: Inconsistencies in the preparation of QC samples can introduce variability, affecting the reliability of the analytical method.
